Lab of liver test

ALT- Less amount in liver, 47hrs half life, periportal zone, 100% in cytoplasm, injury>necrosis

AST- Large amount in liver, 17hrs half life, central zone, 80% in mitochondria, 20% in cytoplasm, necrosis>injury

AST/ALT<1- Chronic hepatitis, late stage of acute hepatits, obstructive jaundice, cholangitis, NAFLD

AST/ALT>1- Hypoxia, liver cirrohosis, acute hepatitis, alcoholic hepatitis

ALK-P(<100)- Bile canalicular membrane, Rise→ abnormal in alimentary, liver, kidney, placenta, bone

GGT(<60)- Bile duct epithelial cell, Rise→ Cholangiocarcinoma, CBD stone, DM, drug, PBC, PSC, alcohol

Bilirubin- Direct(0.2)(Albumin bound half-life 17 days), Indirect(1.0)(Half-life 4 hrs)

Conjugated hyperbilirubinemia- Dubin-Johnson’s syndrome, Rotor’s syndrome, viral or drug induced hepatitis, intrahepatic cholestasis (Sepsis, post-op, PBC, sex hormone, erythromycin), extrahepatic biliary obstruction(CBD stone, cholangiocarcinoma, pancreatic cancer)

Unconjugated hyperbilirubinemia-  hemolysis(ABO, Rh, spherocytosis, G6PD, sickle cell, thalassemia, streptomycin, Vitamin K), non-hemolysis(hematoma, polycythemia, cystic fibrosis), conjugation↓(breast milk, hypothyroidism, Gilbert, Crigler-Najjar)

Published by Steve Johnson

I am a doctor who like to organise knowledges and share ideas with others. As a doctor, a lot of knowledges influx everyday and need some patient to organise and absorb. Here was my notes to share with you and hope to save your time to know it.

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