Nephrotic syndrome

Criteria- Serum albumin<2.5, Proteinuria>3.5g, cholesterol>200, edema

PrimaryMCD, FSGS, MGN, MPGN
SecondaryDiabetic, amyloidosis, cryoglobulinemia, Lupus

Treatment- ACEi, ARB, Na restriction, diuresis

Complication- Thrombosis, infection


1.Minimal change disease (MCD)

Forward- Children most common

Etiology- Insect bites, NSAID, Rifampin, Hodgkin disease, Interferon, HIV

Pathology- Podocyte disappear, epithelial cells foot process effacement, heparan sulfate proteoglycan 喪失

Treatment- Corticosteroid for 1~12 y/o

2.Membranous nephropathy (MGN)

Prevalence- 30~50 y/o male, adult more common

Etiology- SLE, RA, HBV, HCV, NSAID, lung/breast/colon cancer, penicillamine, captopril, syphilis

Pathology- IgG&C3 in subepithelial, spike appearance(silver stain)

Complication- Venous thrombosis in renal vein

3.Focal and segmental glomerulosclerosis (FSGS)

Etiology- HIV, HBV, Parvovirus, HTN, heroin, cholesterol emboli

4.DM nephropathy

Pathology- Kimmelstiel-Wilson lesion

5.MPGN


Published by Steve Johnson

I am a doctor who like to organise knowledges and share ideas with others. As a doctor, a lot of knowledges influx everyday and need some patient to organise and absorb. Here was my notes to share with you and hope to save your time to know it.

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