Lung cancer

Type

1.Adenocarcinoma

Site- Peripheral

Gene- Ras

2.Squamous cell carcinoma

Site- Central

Characteristic- Central necrosis, cavitation, keratinization, stratification, intercellular bridge formation, Pancoast tumor

3.Large cell undifferentiated carcinoma

Site- Peripheral

Pathology- Anaplastic pleomorphic cells

4.Small lung cell cancer

Site- Central


Paraneoplastic syndrome

1.Adenocarcinoma- Hypertrophic pulmonary osteoarthropathy(HPO), migrating thrombophlebitis, NBTE

2.Squamous- HyperCa, Horner syndrome3.Small- SIADH, Cushing syndrome, Eaton Lambert syndrome, polyneuropathy


Treatment

a)Non-small cell lung cancer (NSCLC)

1.Stage I→ Surgery

2.Stage II→ Surgery + chemotherapy

3.Stage IIIA→ Neoadjuvant C/T + surgery

4.Stage IIIB & IV→ First line(Cisplatin + Pemetrexed/Gemcitabine/Vinorelbine/Paclitaxel + Bevacizumab(adenocarcinoma)), Second line(Gefitinib, Erlotinib)

*Good factor of TKI- Exon 19(L747-S752 deletion, E746-A750 deletion), Exon 21 L858R→ Asian female, non-smoker

*Poor factor of TKI- Exon 20 T790M


b)Small cell lung cancer (SCLC)

*PCI- Prophylactic cranial irradiation

Published by Steve Johnson

I am a doctor who like to organise knowledges and share ideas with others. As a doctor, a lot of knowledges influx everyday and need some patient to organise and absorb. Here was my notes to share with you and hope to save your time to know it.

Leave a comment

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: