Lung cancer



Site- Peripheral

Gene- Ras

2.Squamous cell carcinoma

Site- Central

Characteristic- Central necrosis, cavitation, keratinization, stratification, intercellular bridge formation, Pancoast tumor

3.Large cell undifferentiated carcinoma

Site- Peripheral

Pathology- Anaplastic pleomorphic cells

4.Small lung cell cancer

Site- Central

Paraneoplastic syndrome

1.Adenocarcinoma- Hypertrophic pulmonary osteoarthropathy(HPO), migrating thrombophlebitis, NBTE

2.Squamous- HyperCa, Horner syndrome3.Small- SIADH, Cushing syndrome, Eaton Lambert syndrome, polyneuropathy


a)Non-small cell lung cancer (NSCLC)

1.Stage I→ Surgery

2.Stage II→ Surgery + chemotherapy

3.Stage IIIA→ Neoadjuvant C/T + surgery

4.Stage IIIB & IV→ First line(Cisplatin + Pemetrexed/Gemcitabine/Vinorelbine/Paclitaxel + Bevacizumab(adenocarcinoma)), Second line(Gefitinib, Erlotinib)

*Good factor of TKI- Exon 19(L747-S752 deletion, E746-A750 deletion), Exon 21 L858R→ Asian female, non-smoker

*Poor factor of TKI- Exon 20 T790M

b)Small cell lung cancer (SCLC)

*PCI- Prophylactic cranial irradiation

Published by Steve Johnson

I am a doctor who like to organise knowledges and share ideas with others. As a doctor, a lot of knowledges influx everyday and need some patient to organise and absorb. Here was my notes to share with you and hope to save your time to know it.

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