B-lactam antibiotics


*Cr=50 ml/min(50~75%), 10 ml/min(25~33%)

*Carboxy-PCN- Fluid overload, Platelet↓

*B-lactamase- MSSA → Oxacillin

*PBP change- MRSA, PRSP → vancomycin

2. Cephalosporins

*AmpC B-lactamases- E.coli, K.p → Cefepime, Cefpirome, Imipenam, meropenam

*ESBL B-lactamases- E.coli, K.p → Imipenam, Meropenam, Cephamycin

*Serine/Metallo-B-lactamse- MDRAB → Tigecycline

*Cefoperazone and ceftriaxone– Liver metabolism


*Imipenam → seziure


Published by Steve Johnson

I am a doctor who like to organise knowledges and share ideas with others. As a doctor, a lot of knowledges influx everyday and need some patient to organise and absorb. Here was my notes to share with you and hope to save your time to know it.

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