B-lactam antibiotics

1.Penicillin *Cr=50 ml/min(50~75%), 10 ml/min(25~33%) *Carboxy-PCN- Fluid overload, Platelet↓ *B-lactamase- MSSA → Oxacillin *PBP change- MRSA, PRSP → vancomycin 2. Cephalosporins *AmpC B-lactamases- E.coli, K.p → Cefepime, Cefpirome, Imipenam, meropenam *ESBL B-lactamases- E.coli, K.p → Imipenam, Meropenam, Cephamycin *Serine/Metallo-B-lactamse- MDRAB → Tigecycline *Cefoperazone and ceftriaxone– Liver metabolism 3.Carbapenams *Imipenam → seziure 4.Monobactam